ED pills comparison – Viagra vs Cialis vs Levitra

ED medication comparison of erectile dysfunction treatments Viagra, Cialis and Levitra.

Tackling impotence with Phosphodiesterase Type 5 (PDE5) Inhibitors

ED pills comparisonThe following ED pills comparison study examines the all aspects of the 3 most prescribed ED treatments. These 3 PDE5 inhibitors are the basis of popular ED pills Viagra, Cialis and Levitra.

Tadalafil is the active ingredient in the ED medication Cialis®, manufactured by Eli Lilly. It is the longest lasting of the 3 main ED medications.

Sildenafil is the active ingredient of the ED medication known as Viagra®, a registered trademark of Pfizer who also manufactures this well-known brand.  In 1998 Viagra achieved FDA approval for this first erectile dysfunction in 1998.

Vardenafil, another PDE5 inhibitor is the active ingredient Levitra®, manufactured and distributed by Bayer Pharmaceuticals, a German company most known for its flagship medication Asprin.
ED pills price comparison

The stigma surrounding the condition of erectile dysfunction is dissipating

The discomfort around the treatment of ED, is still present but currently, has decreased. This improvement, to some extent, was a result of the introduction Viagra in 1998 that altered erectile dysfunction treatment. Since then, the popular knowledge of impotence has increased, as has the requests for treatment of impotence.

Concerning the current choices to treat ED, oral phosphodiesterase type 5 (PDE5) inhibitors such as Sildenafil (Viagra), Tadalafil (Cialis) and Vardenafil (Levitra) are the proven method. This ED pills comparison will deal with these three ED treatments currently widely available.

As outlined above, this review compares a number of currently licensed PDE5 inhibitors such as Sildenafil citrate, Vardenafil HCl and Cialis.

All these pills have common effects and structural make-ups. Viagra and Levitra have related molecular characteristics. Cialis is molecularly different in its pharmacokinetic arrangement. This maks ED pills comparison a relatively straightforward project.

ED pills comparison – differences between Viagra, Levitra and Cialis

Capability to enjoy an erection that leads to sexual penetration works for 36% of subjects treated with Viagra in 14 minutes. 24% of men who took Levitra within 11 minutes. 17% of men given Cialis within 15 minutes.

Viagra and Levitra both suffer from half-lives of 4 hours but the half-life of Cialis is around 17 hours.

An additional difference between the PDE5 inhibitors is that meals, especially fatty food, modifies the effectiveness of Levitra and Viagra, but not Cialis.

The different pharmacokinetic characteristics among the oral PDE5 inhibitors could influence user choice, an important and emerging aspect of ED pills.

The arrival of Cialis and Levitra extended the number of options for ED treatment. These treatments share the same method of action as Viagra.

This expanded choice of ED pills allows doctors to consider how they compare in terms of efficacy, safety and convenience.

This ED pills comparison considers this issue by offering a comparative analysis of 3 PDE5 inhibitors: Vardenafil, Sildenafil and Tadalafil.

Erectile dysfunction overview

Erectile dysfunction is a failure to achieve an erection of sufficient stiffness for intercourse. It is often due to aging. It becomes more common in men aged forty and older.

In the past, doctors assumed that erectile dysfunction was a mental issue or just a part of getting older. They tolerated ED with other manifestations of age. Now they know that erectile dysfunction is chiefly due to vascular neurological complications.

Erectile dysfunction can also be a marker of many lesser known physical ailments. For example, men with vascular disorders, cardiovascular disease and diabetes.  These ailments can cause a high incidence of impotence.

Crucially, impotence may frequently prove to be an important marker for undiagnosed organic diseases including:

  • hypertension,
  • diabetes,
  • ischaemic heart disease,
  • hyperlipidaemia,
  • neurological conditions
  • endocrine disease.

Despite greater awareness, erectile dysfunction still remains insufficiently diagnosed and treated by the medical establishment. The stigma associated with erectile dysfunction has decreased, but the discomfort of men confiding in their sexual problems continue to form a barrier to sufficient diagnosis and treatment of ED.

The awkwardness many patients and medical establishment workers feel awkward in openly discussing  sexual dysfunction. This fact delays the best diagnosis and treatments available. As a consequence, many men suffer varying degrees of ED prior to seeking treatment.

Too many governmental health boards give scant attention to ED. As a result not enough research funds come available to study the condition and its treatments.

Most men who suffer ED are fail to secur sufficient treatment. Many in the medical establishment view this  as a lost opportunity to improve men’s overall health, not just ED.

This ED pills comparison review will help address that imbalance.  It  assists both impotence sufferers and those in the medical establishment a clearer idea of the solutions now available.

The role of PDE5 inhibitor ED treatments

Doctors realize that ED medications improve the overall quality of life of the patient. They restore the sexual stamina of the patient to a former state. In order to facilitate more natural forms of sexual expression there is a preference for long lasting erectile dysfunction treatments.

Lifestyles changes for obese subjects are beneficial. It improves sexual function and decrease rates and severity of erectile dysfunction.

Healthy alternatives to erectile dysfunction medications

One study involving 138 men found that for one-third, simply lifestyle changes improve sexual performance. The 2 most important factors were weight reduction and increased cardioid-vascular activity.

However, the majority the erectile dysfunction levels of a majority of subjects did not significantly improve through lifestyle changes. This underscores the fact that ED treatments can do more to effectively overcome impotence in the wider population.

Intrusive alternatives to oral PDE5 inhibitors (ED pills)

Various treatments for erectile dysfunction, including surgery, pumps, injections and internal splints exist. Understandably most men prefer less intensive ED treatments and tablets are usually the first choice. As a result doctors rarely prescribe the more intrusive treatments for ED. More affordable and effective PDE5 inhibitors are now readily available.

Oral treatments such as Viagra, Levitra or Cialis are easy to take as well as having minimal side effects. They all have a high rate of effectiveness. WHO now stipulates these oral treatments as the preferred treatment of ED in the first instance.

The ED treatments with most success are Viagra, Levitra or Cialis. As a consequence both expectations and successful outcomes of ED treatments have increased.

PDE5 inhibitor Sildenafil marketed as Viagra

The first oral PDE5 inhibitors available was Sildenafil:  Viagra, generic Viagra and other brand names such as Kamagra. After the introduction of Viagra, a range of PDE5 inhibitors has become available. Cialis (Tadalafil) and Levitra (Vardenafil) both having slight different characteristics from the original Viagra.

Doctors prefer PDE5 inhibitors as first treatment for erectile dysfunction. Experts do not recommend these PDE5 inhibitors for men who have previously suffered stroke as well as a host of other medical conditions – such as:

  • kidney disease that requires dialysis;
  • cardiac failure; out-of-control hypertension;
  • seriously low blood pressure;
  • significant liver damage;
  • those who have a history of myocardial infarction and angina.

ED specialists recommend doctors consult the detailed information and prescription recommendations for each individual PDE5 inhibitor available to prescribe.

This is due to the fact that  each oral PDE5 inhibitor (or ED pill) has slightly different pharmacological effects.

ED medications – how they work

Here is how the PDE5 inhibitors of Viagra, Cialis, and other ED pills work:

The penis only becomes erect as a result of sexual stimulation. Sexual stimulation results in the release of nitric oxide. This causes the dilation of the blood vessels to the corpus cavernosum, the body of the penis shaft. This is in turn assisted by the growing presence of cyclic guaosine monophoshate, usually abbreviated to cGMP.

Unfortunately for a lot of men, particularly as they get older, the presence of cGMP breaks down by the increasing presence of PDE5.

Sildenafil, Vardenafil and Tadalafil, active ingredients used in erectile dysfunction treatments such as Viagra, Cialis and Levitra, are PDE5 blockers or inhibitors. By reducing the effect of PDE5 present in aging men, these PDE5 inhibitors allow natural erections to occur.

These PDE5 inhibitors only come into play when the cGMP synthesis is present and active.

Viagra, Levitra and Cialis all require sexual arousal to work

Needless to say, Ed pills that employ these PDE5 inhibitors require sexual arousal to become active and their intervention noticed.

After sexual stimulation subject nitric oxide is emitted from neurological synapses adjacent to the penises corpus cavernosum. As a result there forms an accumulation of cGMP manufactured from Guanosine triphosphate (GTP). This results in the relaxation of the muscle tissue. This leads to an erection to the cavity being filled up with blood. PDE5 inhibitors prevent the breakdown of cGMP.  Consequentially, erections to take place with greater ease.

ED pills that use PDE5 inhibitors as the active ingredient are becoming increasing competitive. These ED treatments utilize structures derived from cGMP. In the case of Viagra and Levitra their actual molecular structures are very similar.

In distinction to Sildenafil and Varenafil, Tadalafil, the active ingredient in Cialis, has a alternate chemical structure. Hoever, it retains the principle characteristics needed for the retardation of PDE5.

The differences in chemical structure can be viewed with the pharmaokinetic characteristics inherent in the PDE5 inhibitor Tadalafil. Also, how it interacts with various PDE isozymes and needs attention in an ED pills comparison.

Chemical characteristics of oral PDE5 inhibitors (ED pills)

PDE isozmes have been identified in 11 separate instances. They have been classified according to their amino acid sequence as well as their sensitivity to inhibition. Lab-based research has indicated that the oral PDE5 inhibitors retard PDE isozymes differently.

By and large all phosphodiesterase type 5 inhibitors used effectively suppress PDE5. Nevertheless, the three PDE5 inhibitors that form the basis of this study, Viagra, Levitra and Cialis, have different characteristics when it comes to inhibiting other PDE isozymes.

Selective inhibition of PDE6 and PDE11

Viagra and Levitra can cause vision distortion but not Cialis

Of the 3 PDE5 inhibitors discussed, some also a show propensity to retard the uptake of PDE6, an enzyme that has a factor in controlling the reception of light to optic nerves.

This inhibition of PDE6 affects the perception of color among subjects. It is often described as a bluish tinge. Studies in the laboratory indicate that Viagra and Levitra can result in retardation of PDE6 and as such introduce a slight distortion of vision.

Cialis does not show a similar propensity for PDE6 inhibition.

Studies have shown that Vardenafil has a threefold predilection to inhibit PDE5 over PDE6. Sildenafil has a sevenfold bias to retard PDE5 over PDE6. Tadalafil on the other hand has a seven-hundred-fold prediction to block PDE5 over PDE6.

Tadalafil has a greater predilection to inhibit PDE11 over both Sildenafil and Vardenafil. The function of PDE11 is unclear however.

The body absorbs oral PDE5inhibitors (ED pills) such as Sildenafil, Tadalafil and Vardenafil quickly into the blood stream after ingestion.

Viagra and Levitra achieve peak concentration and effects before Cialis

After ingestion, Viagra reaches a top concentration slightly less than an hour, Levitra reaches its peak plasma concentration in approximately an hour. Cialis takes up to 2 hours to reach its greatest plasma concentration.

ED pills comparison – The effect of food and alcohol

High fat food present in the subjects stomach prior to ingestion slows down the absorption of Levitra and Viagra. It appears to have little if any effect on the absorption of Cialis.

Effect of Viagra and Levitra reduced by fatty food content

High-fat content delays the absorption of Viagra by 1 extra hour. The peak concentration in the blood stream is decreased overall by 30%.

Similar to Viagra,  high fat content slows down the uptake of Levitra for up to 1 hour. Likewise, the peak plasma concentration is reduced by around 20%.

Cialis unaffected by fatty food intake

On the other hand, the presence of fatty foods do not affect Cialis. One can take Tadalafil with little concern over stomach contents as the effects are constant.

The consumption of alcohol doe not seem to affect all 3 oral PDE5 inhibitors, Cialis, Levitra and Viagra. However, excessive consumption of alcohol remains a factor in erectile dysfunction incidents.

next: ED Pills Comparison part 2 – Viagra vs Cialis vs Levitra



ED & PE combo pills

ED & PE combo pills – best of both worlds

ED & PE treatmentsMany men suffer from premature ejaculation (PE). Many men suffer from erectile dysfunction (ED). Some men suffer from ED and PE.

ED & PE combo pills combine a PDE5 inhibitor (ED med) with dapoxetine (PE med) so those who suffer from ED & PE can overcome both symptoms at the same time.

ED & PE combo pills allow you to enjoy rock-hard erections when sexually stimulated and enable you to enjoy sexual intercourse for as long as you wish.

If you suffer from ED and PE these are the pills that allow you to enjoy a healthy and satisfying sex life for you and your partner(s).

In other words, one pill for all your sexual needs!

First a brief overview of the active ingredients

PE treatment dapoxetine

Dapoxetine is a premature ejaculation prevention medication. Men can control they ejaculations for up to 4 hours after taking 30 to 60mg of dapoxetine.

You can order dapoxetine in two strengths – 30mg and 60mg. The effects of dapoxetine last up to 4 hours after ingestion.

This effective PE treatment medication is sold under a number of different names such as Priligy and Westoxetin.

For more information on these last longer in bed pills see: dapoxetine / Priligy

ED treatments Viagra, Cialis & Levitra

You can get the 3 most popular erectile dysfunction medications, Viagra, Cialis and Levitra in combination with dapoxetine. This allows those men who suffer from both ED and PE to enjoy healthy sex lives with both firm erections and stamina.


Viagra is composed of sildenafil, a PDE5 inhibitor which enables strong erections when sexually stimulated for up to 6 hours after ingestion.

For more information on Viagra / sildenafil click: Viagra


Cialis is composed of tadalafil, a PDE5 inhibitor known for its long lasting effects. 20mg of tadalafil can last for up to 36 hours after ingestion.

For more information on Cialis / tadalafil click: Cialis


Another PDE5 inhibitor, Levitra is composed of Vardenafil. Known for its rapid and strong effects, Vardenafil can lst for up to 8 hours after ingestion.

For more information on Levitra, click: Levitra

ED & PE Combo 1 – Viagra + dapoxetine

Viagra + dapoxetine combo pillThis ED & PE combo pill combines 100mg of Sildenafil with 60mg of dapoxetine.

This strength should cure most cases of ED and PE. For those who only suffer mild forms of ED and PE, half a dose should suffice.

The price comparison table below includes a bone-fide online pharmacies that supply Viagra + dapoxetine combo pills at very competitive prices, along with good customer service and high quality medications.

You can buy ED & PE combo pills from any of these pharmacies with confidence.

Viagra + dapoxetine 100mg / 60mg

Viagra + dapoxetine is a combination erectile dysfunction pill containing 100mg of sildenafil PDE5 inhibitor with 60mg of dapoxetine premature ejaculation cure.

A half dose (50mg/30mg) will suffice for most men. Full dose (100mg/60mg) for those who suffer severe ED and PE.

Effects of sildenafil last up to 6 hours. Effects of dapoxetine last up to 4 hours.
PharmacyDeliveryPriceOrder page
Airmail $10 (Free for orders over $200)
Express & trackable $20.81
from $1.59 per pill

ED & PE Combo 3 – Cialis + dapoxetine

cialis + dapoxetine combo pillAlthough not as popular, Cialis + dapoxetine combo pills area available. 20mg of Cialis (tadalafil) will enable you to enjoy powerful erections when sexually stimulated for up to 36 hours.

The effects of dapoxetine however, will only last for around 4 hours.

For men who suffer from ED more than PE, this may be a good ED & PE combo pill.

All pharmacies listed in the price comparison table below offer top quality service and medications.

Cialis + dapoxetine 20mg / 60mg

Cialis + dapoxetine is a combination erectile dysfunction pill containing 20mg of tadalafil PDE5 inhibitor with 60mg of dapoxetine premature ejaculation cure.

A half dose (10mg/30mg) will suffice for most men. Full dose (20mg/60mg) for those who suffer severe ED and PE.

Effects of tadalafil last up to 36 hours. Effects of dapoxetine last up to 4 hours.
PharmacyDeliveryPriceOrder page
Airmail $10 (Free for orders over $200)
Express & trackable $20.81
from $7.65 per pill

ED & PE Combo 3 – Levitra + dapoxetine

levitra + dapoxetine combo pillLevitra is composed of PDE5 inhibitor vardenafil  is a top selling ED medication.

Combined with dapoxetine this ED & PE combo pill is known for its fast action and effectiveness.

The effects of Levitra / vardenafil last for up to 8 hours after ingestion.

Levitra is known as one of the most reliable and effective ED medication testified by it popularity.

Check out the Levitra + dapoxetine combo pills price comparison table below to select the right price and quantity for yourself.

Levitra + Dapoxetine 20mg / 60mg

Levitra + dapoxetine is a combination erectile dysfunction pill containing vardenafil PDE5 inhibitor 20mg and dapoxetine 60mg premature ejaculation cure.

This combo pill will enable a man to achieve a significant and long lasting erection when sexually aroused without suffering PE.

Vardenafil remains effective for up to 8 hours. Dapoxetine remains effective for up to 4 hours.
PharmacyDeliveryPriceOrder page

Free International Airmail.
Express & trackable $20
from $6.25 per pill
+Viagra Soft 100mg x 4 pills
+Cialis Soft 20mg x 2 pills
Airmail $10 (Free for orders over $200)
Express & trackable $20.81
from $2.10 per pill
+ 10 free ED pills

Buying ED & PE combo pills

ed & pe combo pillsIf you do experience both ED and PE, then it’s also cheaper to buy ED & PE combo pills that buy both ED & PE pills separately.

If however, you only suffer from ED or PEW, but not both, it is a little cheaper to buy an ED only pills or a PE only pill suited to your condition

I have shopped at the pharmacies listed above for all my  medications. You will find that they have the best prices as well as free or low cost delivery worldwide. All orders are sent in discreet packaging.

These online pharmacies are a sorting-house for laboratories around the world which manufacture generic drugs. The prices are cheap compared to main street pharmacies because they cut out unnecessary costs of middlemen.

Generic medications, although identical to brand name medications in composition and quality, due not carry the patent costs imposed by large intentional pharmaceutical companies.

These online pharmacies require you to have a doctor’s approval when ordering ED & PE combo pills. But no worries, a reasonably brief and simple consultation process id built into the checkout procedure.

Simply answer a few question about your health and other medications you may be taking. A trained professional will review your answers and the order will have approval usually withing minutes.

If for some reason you are not approved for ED & PE combo pills, no charge to you will occur. The prescription consultation process is provided free of charge with all the online pharmacies listed in the price comparison tables listed above.