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Cialis® is the brand name for Tadalafil, a drug that cures erectile dysfunction. It is produced by pharmaceutical company Eli Lilly. The active ingredient called Tadalafil. In the USA, Eli Lilly held the patent on Tadalafil until 2016, so generic Cialis wasn’t available till after the patent expired.

However, generic Cialis has been available long before then because in India, Eli Lilly is not allowed to hold a patent for Tadalafi. Pharmaceutical laboratories in India can manufacture and market their own versions of cheap generic Cialis and have been doing so for years.

Don’t let the description, cheap generic Cialis put you off. These pills are made to the same standards as brand name Cialis. It’s not uncommon for drug manufacturers in India to be making brand name drugs for large pharmaceutical companies like Eli Lilly for sale in the USA while at the same time producing generic versions of the same drig for sale elsewhere.

So you have the exact same drug produced at same laboratory yet sold for substantially different prices.

Generic Cialis is often just sold by its active ingredient’s name: tadalafil. It is also marketed as:

  • Tadalafil citrate,
  • Adcirca,
  • Tadacip,
  • Apcalis,
  • Tadalis SX
  • Tadanafil.

Cialis 20mg

Generic Cialis erectile dysfunction pill containing Tadalafil PDE5 inhibitor 20 milligrams. One pill will enable a man to achieve a significant and long lasting erection when sexually aroused. Cialis remains effective for up to 36 hours.
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How Does Cheap Generic Cialis Work?

Cialis, or Tadalafil, is similar to Viagra in that it helps men who experience difficulty in achieving and maintaining erections. The main difference between Viagra and Cialis is that the positive effects of Cialis last longer. Much longer. Up to 36 hours as compared to Viagra lasting only 4 to 6 hours.

Although it lasts much longer, Tadalafil still belongs to the same class of drugs called PDE-5 inhibitors like Sildenafil, the active ingredient in generic Viagra, and Vardenafil, the ingredient in Levitra.

PDE5s are chemicals in the body which slow down the production of other chemicals like PDE5 which block blood flow to the penis. Cialis, Viagra and Levitra all work to suppress the production of PDE5 chemicals. This promotes a significant flow of blood to the penis when sexually aroused.

Increased blood flow to the penis is perfectly natural when sexually stimulated. But here’s the catch: ED pills like generic Cialis won’t make you sexually excited. Taking ED pills like Cialis won’t cause you to have erections if you are not sexually stimulated. ED drugs just help you avoid the embarrassment of failing to achieve a raging hard on even tho you find yourself in a sexually stimulating situation.

So the essential difference between Cialis and other ED medications is that Cialis (tadalafil) takes longer to be broken down in the body so its effects last so much longer. The effects of Viagra (sildenafil) or Levitra (vardenafil) generally last for 4-6 hours. However, the effects of Cialis may last for up to 36 hours – a day and a half!

Because Cialis (tadalafil) lasts for so long people call it affectionately-  the weekend pill. It’ll keep you going all weekend! This is why cheap generic Cialis is one of the most sought-after ED medications of all.

So if Cialis lasts so much longer than the other two popular and much-used ED medications, why doesn’t everyone use Cialis?

There are a number of reasons why people chose Viagra or Levitra over Cialis.

The most simple explanation is that people prefer to use what they know. If someone first uses Viagra and discovers it works well for them, they may stick going forward. The same is true for other ED pills on the market.

Others who are willing to try different ED pills to see what works best for them might discover that they find Viagra or Levitra work better for them.

Then again, not everybody wants an ED pill with long lasting effects. The 4 to 6 window that Viagra or Levitra supplies might be more than enough.

How much Cialis? Looking at Tadalafil doses.

tadalafil tabletGeneric Cialis, or Tadalafil, is available in 2.5 mg, 5mg, 10mg and 20mg doses. Higher doses are sometimes available.

Different does reflect two different ways people use generic Cialis.

One way is using it like other ED medications. One takes it when one needs it – before engaging in penetrative sexual activity.

Others may take a small 2.5 mg or 5 mg dose daily so they can engage in sexual activity where and when they need to without suffering erectile dysfunction.

Cialis as needed

The recommended dose for Cialis is 20mg. Some may find that a 10mg dose is enough. The suitable dosage may depend of a number of factors including severity of ED and sensitivity to tadalafil. Best to take a dose 20 minutes before sexual activity, but no need take it more than once a day. Remember, its effects can last for up to 36 hours.

Cialis once a day

The EU Commission and the FDA approved the sale of Cialis in 2.5 mg doses, as a treatment to take daily. This removes some of the inconvenience of having to think ahead by taking Cialis ahead of sexual activity. However, in this case it’s important to stick to this smaller dose.

Cialis side effects are rare

Taking Cialis occasionally has a few side-effects. These effects are caused by the fact that tadalafil helps relax blood vessels and may temporarily lower blood pressure.

Tadalafil side effects include:

  • headache,
  • stomach discomfort or pain,
  • indigestion,
  • burping,
  • acid reflux.
  • back pain,
  • muscle aches,
  • flushing,
  • stuffy or runny nose.

It’s best to avoid Cialis if you’re on medications containing organic nitrates – or other blood pressure-lowering medications. Have a chat with your doctor if you’ve any concerns.

There are some reports of people suffering sudden loss of hearing after taking it, but this is very rare. Again, consult your doctor if you experience any problems.

Where to buy generic Cialis online?

Ah yes, the 64 thousand dollar question. Or is it the $1.18 question? – considering this is the price at which you can buy cheap generic Cialis per pill online.

After much internet research, I finally found some decent online suppliers where I could buy high quality but cheap generic Cialis and other ED medications at great prices.

Remember, it’s important to be discerning where you buy Cialis online because even if it’s generic, it might not be that cheap.

For example, some online drugstores generic Cialis for $9 or more a pill! And that’s half the price of Eli Lilly branded Cialis!!

Another way to save money is by buying Cialis at a larger dose like 40mg. Just snap it two for two doses of 20 mg. Larger dose pills are cheaper per half dose. For example, it’s nearly the same price per pill to buy 20mg Cialis pills than 10mg pills. Cut them in half to get double the number of doses.

Compare prices to find cheap Tadalafil 20 mg (generic Cialis) on-line

The much talked about erectile dysfunction medication Cialis is actually composed of a PDE5 inhibitor called Tadalafil – so cheap Tadalafil is really just another way to say cheap generic Cialis.

Tadalafil 20 mg is a sufficient amount for most men to enjoy sufficient erections when sexually stimulated for up to 36 hours. (The half-live of Tadalafil is 17 hours. In other words, after 17 hours 10 mg of Tadalafil will still be active if you have taken a Tadalafil 20 mg pill.)

Tadalafil 20 mg – How it works

Don’t be put off by the term ‘inhibitor’. It might sound like it might stop you from enjoying great erections and awesome sex but actually the opposite is true.

A PDE5 inhibitor blocks to deterioration of cGMP allowing blood to flow more freely to the penis. Or in other words, it prevents your body from stopping itself from getting an erection when sexual arousal is in the air.

Unlike Sildenafil Citrate, or generic Viagra, Tadalafil lasts much longer. Whereas Viagra is effective from 4 to 6 hours after ingestion, while the effects of Tadalafil 20 mg (aka Cialis 20 mg) last 36 hours or more giving it the title ‘the weekend pill’.

Cialis 20 mg = Tadalafil 20 mg

Marketed as Cialis® patented by Eli Lilly Pharmaceuticals since 2003, Tadalafil has been very popular with men.

Unfortunately, Cialis® is very expensive and costs of $6 to $10 a pill is regularly charged at drug stores – even after you get a prescription.

Now due to an increasing global economy and the Internet you can now order genuine but low cost Tadalafil 20 mg online without a prescription and have it delivered to your door in discreet packages.

How to get cheap Tadalafil 20 mg

If you wish to take Tadalafil daily and be ‘Mr Ever-ready’ 10mg of Tadalafil is the usual prescription. For an extra strong dosage for a one off time you can double the dosage to 20mg.

However, regardless of the amount of Tadalafil, the cost of production remains roughly the same.

Hence you can get a bulk buy of cheap Tadalafil 10mg pills for $0.90 each.

If you buy the same amount of cheap Tadalafil 40mg pills it will cost you only $1.04 per pill – or $0.26 a dose if you were to split the pill into four separate doses.

So the way to get dirt cheap Tadalafil is to buy the higher strength pills and them simply take as much as required – 10mg or 20mg at a time.

(By the way, I’ve never heard of an ‘overdose’ on Tadalafil 20 mg. As far as I’m aware, taking more Tadalafil than is needed will only increase the chances of experiencing side effects like headache or muscle pains but nothing too drastic or life-threatening.)

I get all my cheap Tadalafil 20 mg from Expredd because the pills are genuine Tadalafil 20 mg – produced by high quality generic medication laboratories. They offer free shipping in discreet packaging. If your in a rush you can pay a little extra to have your order sent to you express.

Cialis 20mg

Generic Cialis erectile dysfunction pill containing Tadalafil PDE5 inhibitor 20 milligrams. One pill will enable a man to achieve a significant and long lasting erection when sexually aroused. Cialis remains effective for up to 36 hours.
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* Remember that Cialis 20 mg is the same thing as Tadalafil 20 mg. Tadalafil is the active ingredient of Cialis.

Generic Cialis pills facts

Generic Cialis pills online

cialisThere is no shortage of misinformation about Cialis. It is spread by the mass media and entertainment industry.

The first misunderstanding is the notion that generic Cialis pills are only for the cure of severe impotence.  That is when a man can no longer achieve erections.

Cialis is a great remedies impotence, granted. But it is an error to confine its usefulness to that purpose only.

Cheap generic Cialis consists of tadalafil, the identical ingredient to brand name Cialis. is a reawakening to men who suffer ED. It also works for men who desire extra strength and endurance during intercourse. It increases confidence and delivers greater satisfaction.

Some men may experience negative side-effects when using Cialis. However these side effects are forunately rare.

The active ingredient of generic Cialis is PDE5 inhibitor tadalafil – the same ingredient found in the brand name version. Therefore the only real difference is price.

ED pills online price comparison

If you’re thinking about trying generic Cialis pills, keep this in mind

How old should you be to try Cialis?

You don’t have to be old, or suffer ED to enjoy the benefits of Cialis pills.

The fact is men are in their sexual prime in their early to mid-20’s. On the other hand, many women who do not achieve their sexual prime until their late 30’s or 40’s.

After 30 it’s a gradual decline in sexual ability to stay erect. In addition this is coupled by increased loss of confidence. For men over 30, using Cialis can wind back the clock to your peak years. You’ll be performing sexual activity like the good old days.

Increased capacity and confidence with Cialis

With Cialis pills and other ED treatments, you will experience stronger erections for greater duration. You can enjoy great sex more often and increased confidence.

Some feel discomfort buying generic Cialis pills and other ED pills. This instigated and broadcast by the news and the entertainment industry.

Popular entertainment connects using ED pills with deception and desperation. ED pills such as Cialis are often associated with shame. This is really sad.

Overcoming the shame of erectile dysfunction

The fact is that the gradual loss of sexual potency is the result of ageing. Yet there remains a false embarrassment attached to Cialis and other ED pills.

There should be no shame in using generic Cialis pills or other ED medications to combat natural decline in sexual potency.

One needs to transcend the stigma and associate ED treatments like Cialis as confidence treatment.

How to avoid the embarrassment of talking about ED

A lot of men are put off because a doctor’s prescription is needed to get Cialis. But it is understandable that most men do not want to to confess their impotence with others. The answer is buying Cialis online.

One just needs to answer some questions concerning allergies and other prescription medication you take. The application usually gets the go ahead within a few minutes. An order of generic Cialis pills arrives at your home in a discreet package in a few days.

The cost of ED pills such as Cialis is sufficient to dismay a lot of men. Mind you. Pharmaceutical manufacturers produce generic Cialis pills at a fraction of the brand-name cost. You can get generic Cialis with the identical ingredients to the brand Cialis at a much lower price. You can get 6 months or a year’s supply of Cialis for as little as 15 cents a dose. Discover how to get cheap generic Cialis prices at this link: cheap generic Cialis.

ED pills pave the path to a happier life

Cialis ED pillsThe above thoughts should have given you some knowledge into the enhancements of using Cialis to substantially improve your sex life for you as well as your lover.

The media continues to spread misinformation about ED pills and Cialis. It makes out there must be something wrong with you if you are taking get hard pills. But you need strong erections for fulfilling sex life. It is a path to a happier and higher quality life.

To sum up, there are different makes of erectile dysfunction pills you can get and there are significant differences in results such quickness and period of effectiveness.

If you’re still not sure what may be best for you I would suggest you to try an ED trial pack.

For very low cost you can have a range of ED pills available from an on-line pharmacy.

They all work in helping you enjoy hard erections when sexually excited. You will probably discover that some impotence pills work better for you than other types.

Tadalafil

Tadalafil aka Cialis

tadalafilTadalafil is the ingredient of Cialis®. Eli Lilly makes and  patents it. If you go for the Cialis brand it can cost you up to $10 a pill in some places. However, thanks to the world wide web you can now buy generic versions of Cialis much much cheaper.

Generic versions of Cialis are exactly the same as brand name Cialis – they all contain Tadalafil.

How Tafalafil works

Tadalafil works in much the same ways as Sildenafil Citrate – the key ingredient in Viagra and generic Viagra. Both are what are called phosphodiesterase 5 (PDE5) inhibitors.

But don’t worry – it’s not you they inhibit! Quite the opposite. PDE5 is a chemical which has the effect of reducing blood flow to the penis. Inhibiting PDE5 allows the full flow of blood. It means you have no problem getting and maintaining a good hard erection.

Some people think erectile dysfunction drugs work by instantly getting you hard. But if you do not feel sexually stimulated, nothing will happen. What ED pills do is to stop your body getting in the way of its own sexual responses.

Another bonus of tadalafil is that it lasts for longer than Viagra (sildenafil) – up to 36 hours! So its nickname is ‘the weekend pill’. And it sure does liven up the weekend 😉

It’s also the only ED medication approved for use on a daily basis – so you’re always ‘ready’… But if you’re taking it this way, you take a much smaller dose (e.g., 2.5mg).

Or you can just take it ‘as needed’, about an hour before sexual activity.  10mg is recommended to start with.

For information on dosage, and more on how tadalafil works, see my post here on cheap generic Cialis

(This post also lists possible side effects and drug interactions. If you have any concerns about taking tadalafil, talk to your doctor.)

Where to get tadalafil online

tadalafil pillAs I mentioned above, I’ve done a price comparison table so you can see where to buy tadalafil online for the best prices.

The best places to order these ED pills are from international generic medication laboratories. They can get the cheapest prices straight from the suppliers, and pass those on to the consumer. Then you can avoid the price hike added on by a lot of online pharmacies.

I’ve personally found them to be very reliable and their pills to be consistently good quality. Another bonus is that shipping is free worldwide.

Usually if you buy cheap tadalafil online it’ll arrive 7-10 days later. You can pay extra to get faster delivery if you want. It arrives in plain discreet packaging.

You can save even more money by buying in bulk. You could also buy higher dose pills and splitting them into smaller doses.

Cialis 20mg

Generic Cialis erectile dysfunction pill containing Tadalafil PDE5 inhibitor 20 milligrams. One pill will enable a man to achieve a significant and long lasting erection when sexually aroused. Cialis remains effective for up to 36 hours.
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Erectile Dysfunction Pills Online

ED pills online – the lowdown

erectile dysfunction pills onlineIt’s getting easier and easier to buy cheap erectile dysfunction pills online as the market in generic medications grows worldwide.

This fact is in part a response to the huge demand for erectile dysfunction pills online. There are two reasons for that fact.

First ED pills work for the vast majority of men. Clinical test prove that they work. The experience of millions of men prove that ED pills are an effective cure for they erectile dysfunction woes.

There is another reason that erectile dysfunction pills online are so popular. The pharmaceutical companies who have patented these drugs are charging over-the-moon prices for them. This, despite the fact they only cost only pennies to make.

The response of the free market has been overwhelming. Generic ED pills available from high quality pharmaceutical laboratories, many based in India, are now easily available online for only a fraction of the prices Big Pharma charges.

The video posted above is a good example of how wrong many ‘relationship experts’ are. They get it all wrong comes to dealing with erectile dysfunction issues.

Many woman think its a psychological problem that simply needs to be “talked about”.

Erectile dysfunction may be a psychological problem for a few men.

But the majority of men who suffer ED it is a physiological problem. A problem that can be easily remedied by oral PDE5 inhibitors like Viagra, Cialis or Levitra.

ED pills online price comparisons

Check out my price comparison tables for cheap erectile dysfunction pills online:

ED pills price comparison

When erectile dysfunction (ED) medication was first marketed, you could only get the expensive brand-name stuff. For example, when Viagra was first launched, Pfizer held all the patents for the key ingredient of Viagra, and it was the same story for several of the other new ED drugs too.

However, in most countries the patent for Viagra has now expired (or in the case of Canada, been invalidated by the courts), which means generic Viagra is legally available in Canada, the UK, and many other countries (not the US though, where Pfizer’s patent doesn’t expire till 2020).

Other popular ED drugs have now become available too, such as Cialis (Tadalafil) and Levitra (Vardenafil), and are now available in generic versions, so you should have no trouble buying cheap erectile dysfunction pills online these days.

Best Place for Cheap Erectile Dysfunction Pills Online

There’s still a question over where to get the best deal though when you’re buying cheap erectile dysfunction pills online. Some online drug stores still charge through-the-nose prices – almost as much as the branded ED pills – sometimes as much as $5 or $10 a pill!

There are good pharmacies where you can buy genuinely cheap erectile dysfunction pills online. This is the place I now buy all my ED pills as they’re both reliable and very cheap. They’re a sorting-house for international laboratories which manufacture generic ED medication, so by shopping with them you’re getting your ED pills from closer to the source and this means the costs are lower.

Cheap ED Pills Trial Packs

ED trial packsThere are several types of cheap erectile dysfunction pills online. If you’re not sure which ones are most suitable for you, you can always try an ED pill trial pack.

These contain the three top-selling generic ED medications: generic Viagra (Sildenafil), generic Cialis (Tadalafil), generic Levitra (Vardenafil).

You can buy a pack with all three, or with any combination of just two of them:

Cheap ED Pills Trial Pack

To find out more about the different types of cheap erectile dysfunction pills online, see these posts:

Generic Viagra / Sildenafil

Cheap Generic Cialis / Tadalafil

Cheap Generic Levitra / Vardenafil

Do I Need a Prescription to Buy Erectile Dysfunction Pills Online?

With some pharmacies, you do need a doctor’s prescription even to buy generic cheap erectile dysfunction pills online. However, with online pharmacies highlighted in our erectile dysfunction pills online price comparison tables you don’t need a prescription.

Instead, you’ll get asked some questions about your health and background when you place your order, and a doctor will look over your answers and approve your order (assuming there are no medical reasons that you shouldn’t be taking that medication). This doesn’t usually take more than a few minutes, and you only have to do this the first time you buy that particular cheap erectile dysfunction pill online.

Tips on Buying Erectile Dysfunction Pills Online

As well as buying ED pills from the cheapest sources online, you can also save money by buying in bulk and by buying larger doses and splitting them down to smaller doses.

This is described in detail in this post. It’s about buying cheap Viagra, but the same principles apply to buying any cheap erectile dysfunction pills online and following these tips guarantees you get the absolutely lowest-cost ED pills possible:

Buy Sildenafil Citrate Online – Top Money Saving Tips!
Enjoy, Ed.

 

ED pill comparison

Cialis, Viagra and Levitra – ED pills compared

Curing erectile dysfunction using Phosphodiesterase Type 5 inhibitors

ED pill comparisonThis ED pill comparison looks at characteristics of the 3 most popular erectile dysfunction medications. Phosphodiesterase Type 5 Inhibitors (PDE5 inhibitors) are the active ingredients in all erectile dysfunction (ED) pills.

Sildenafil is the PDE5 inhibitor of Viagra®, a registered trademark of Pfizer.  Pfizer also manufactures this well-known brand. Sildenafil was the initial PDE5 inhibitor (or ‘blocker’) granted approval for the treatment of ED in 1998.

Tadalafil is the PDE5 Inhibitor of Cialis®. It is a registered trademark of pharmaceutical Eli Lilly. Some people call Cialis ‘the weekend pill’.  It is the longest lasting ED pill of the 3 main impotence drugs.

Vardenafil, another PDE5 inhibitor, is the basis of Levitra. Bayer Pharmaceuticals, a German company most known for its flagship medication Aspirin, distributes Levitra®.

ED pills price comparisonSocial stigma of ED is decreasing

The stigma surrounding the condition of impotence is still present but is decreasing. This improvement is partly due to the easy availability of Viagra. Since then, the popular understanding of ED has grown with increased demand for ED pills.

Regarding the available pills to cure ED,  this ED pill comparison deals with these ED pills currently available.

This ED pill comparison details the 3 effective oral PDE5 inhibitors such as Vardenafil (Levitra), Tadalafil (Cialis) and Sildenafil (Viagra).

Each of the ED pills have similar results and have complimentary chemical structures. Vardenafil and Sildenafil have related molecular characteristics. Tadalafil is structurally distinct.

ED in the male population – recent findings

erectile dysfunction stigmaErectile dysfunction, often referred to as ‘impotence’, is an inability to achieve an erection of sufficient stiffness for sexual intercourse. Many people associate ED with getting older. Impotence becomes more prevalent with men over the age of 40.

Previously, the medical establishment considered ED as a mental issue or simply a result of ageing. The medical establishment accepted ED as with other manifestations of old age. These days, many doctors realize that impotence is chiefly biological as a consequence of internal biological processes.

Then again,a number of lesser known bodily misalignments could cause ED. As an example, men with vascular problems, such as cardiovascular disease and/or diabetes, have a high incidence of impotence.

ED may often show to be an important indicator for hidden natural diseases. This includes high blood pressure, diabetes and  heart problems.

Decrease in stigma associated with ED

Men are now more aware of the prevalence of ED. However the condition remains unreported and under-cured by medical professionals. The embarrassment about discussing ED has decreased. But the stigma felt by many men persists. This creates a barrier to sufficient understanding and treatment of ED.

Many men feel uncomfortable discussing their ED problems This includes medical professionals involved in consulting roles. The result is a delay of ED pill uptake.

Hence, countless men suffer ED prior to demanding medications to treat ED.

Often the medical establishment gives little regard to the condition of ED. As a result there is clearly not enough funds set aside for ED treatments.

A lot of men who suffer ED are poorly treated. This is despite the fact that they would have much to gain from proper diagnosis and treatment. The results is a misplaced chance to enhance men’s general and mental health, not just ED.

The following ED pill comparison examines this imbalance. It also offers some guidelines to improve the treatment of men who suffer ED.  The medical establishment needs a more focused view of the solutions currently available.

The role of oral PDE5 inhibitor in ED pills

ED pills enhance the sexual life of men. It can reawaken their sexual capacity to a previously enjoyed condition. There is a preference for ED pills that extend the time of effectiveness. This allows more unplanned sexual encounters.

Also, changes in lifestyle for men considered obese are beneficial to improve sexual function. It also decreases the incidence of ED through weight reduction and increased aerobic activity.

However, lifestyles changes alone did not cure ED for most subjects. This clearly demonstrates that the majority of ED sufferers still need ED pills.

Intrusive alternatives to PDE5 blocker medications (ED pills)

The medical establishment has explored various cures for ED including injections and surgery. Statistics show the majority of patients prefer less intensive methods  and ED pills are frequently the first choice.

Consequently the medical establishment is phasing out the more costly treatments for ED. More affordable and effective generic PDE5 inhibitors become are available on the internet or from a clinic.

ED pills like Levitra, Cialis and Viagra are simple to use. They also enjoy few side effects and a high rate of success.

Accordingly the World Health Organization (WHO) consider ED pills ,namely Viagra, Cialis and Levitra, as the recommended treatment of ED.

The ED pills with the highest track record of effectiveness are PDE5 blockers such as Viagra, Levitra and Cialis. As a consequence both the success rate of ED pills have improved.

Oral PDE5 inhibitor Sildenafil called Viagra

Viagra pillThe first PDE5 blocker to to be used extensively was Sildenafil marketed as Viagra.

Sildenafil is also available online as generic Viagra. Vardenafil (Levitra) and Tadalafil (Cialis) are the most well known ED pills after Viagra. Tadalafil and Vardenafil have slightly different effects to the original PDE5 blocker Viagra.

The PDE5 inhibitors are the preferred initial treatment for ED. These ED pills are not suited for men who have previously suffered stroke. Also a range of other health conditions like:

  • kidney disease that requires dialysis;
  • heart defects;
  • excessive hypertension;
  • seriously hypo-tension;
  • substantial liver disease.

In these cases doctors are encourages to examine the detailed information for each particular PDE5 inhibitor available to dispense.

This is because ED pill have slightly alternate pharmacological effects on the patient. Nevertheless,  all 3 PDE5 blockers, Viagra, Levitra and Cialis are similar.

How do ED pills work?

This is the method by which the oral PDE5 inhibitors of Levitra, Viagra, Cialis, and other ED pills function:

The penis only becomes engorged in response to sexual situations. Erotic stimulus results in the creation of nitric oxide. This results in the dilation of the arteries and veins to the corpus cavernosum, the body of the penis. It is in turn assisted by the increasing presence of cyclic guaosine monophosphate (cGMP).

As men get older, the levels of cGMP required for erections is broken down by the growing presence of PDE5.

By degrading the presence of PDE5 (increasingly present as men age), these PDE5 inhibitors allow sufficient erections to come about.

PDE5 inhibitors only become activated when cGMP synthesis is present.

All ED pills require erotic arousal to activate

Needless to say, erectile dysfunction pills that use PDE5 blockers require sexual stimulus to become active.

During sexual stimulation of the male subject, nitric oxide is created from nerve endings beside to the penises corpus cavernosum. As a result there arises a glut of cGMP arising from GTP which results in the relaxation of the tissue which in turn leads to an erection to the cavity being engorged with fluid. Phosphodiesterase Type 5 inhibitors retard the degradation of cGMP which then allows erections to manifest with greater ease.

Erectile dysfunction medications that use oral PDE5 inhibitors as the effective ingredient are becoming very popular. These ED pills employ substances created from cyclic guaosine monophosphate and in the case of Cialis, Levitra and Viagra, their actual molecular makeup are very similar.

In distinction to Viagra and Levitra, Cialis has a slightly different pharmacokinetic property. However it also retards Phosphodiesterase Type 5.

Comparative analysis of the  chemical characteristics of PDE5 inhibitors used by ED pills

Phosphodiesterase enzymes are identified in 11 distinct instances. They are described in relation to to the amino acid structure as well as the reaction produced when blocked or inhibited. Lab-based research has shown that the PDE5 inhibitors used in curing erectile dysfunction inhibit PDE enzymes in distinct manners.

Most PDE5 inhibitors developed inhibit phosphodiesterase type 5. But, the 3 PDE5 blockers discussed here, Tadalafil, Vardenafil and Sildenafil, have distinct effects when it comes to blocking additional PDE enzymes.

Selective inhibition of PDE6 and PDE11 comparative analysis

Out of the three ED pills examined, two show a tendency to block the activation of PDE6, an enzyme that help organize the perception of light by ones optical nerves.

This inhibition of PDE6 affects the experience of color. This distortion is often reported as an enhancement of blue colors in ones field of vision. ED pill comparisons indicate that Sildenafil (Viagra) and Vardenafil (Levitra) occasionally leads to too much retardation of PDE6 and consequently causes a noticeable degradation of sight.

Tadalafil (Cialis) does not usually demonstrate a likewise predilection for PDE6 retardation.

ED pill comparisons have demonstrated that Vardenafil (Levitra) has a 3 times propensity to inhibit PDE5 over PDE6.

Sildenafil (Viagra) has a 7 times propensity to inhibit PDE5 over PDE6.

Tadalafil (Cialis) conversely has a 700 times propensity to retard PDE5 over PDE6.

However, Cialis has a greater bias to retard PDE11 over both Levitra and Viagra. The purpose of PDE11 remains unknown.

All 3 ED pills, Cialis, Levitra and Viagra are absorbed quickly into the blood stream after ingesting.

Time to achieve top blood concentration comparison

Post taking, Sildenafil PDE5 blocker (Viagra) achieves the highest accumulation somewhat less than an hour.

Vardenafil (Levitra) reaches its peak plasma concentration in up to 1 hour.

Tadalafil (Cialis) requires up to 2 hours to reach its highest accumulation.

A comparative look at the affect of food and alcohol on Viagra, Cialis and Levitra

Fatty-based foods in the patient’s stomach prior to taking an ED pill decreases in the absorption of Vardenafil and Sildenafil. However it demonstrates no causal effect on Tadalafil.

Fatty foods delay the absorption of Viagra up to an hour with . The peak plasma concentration in the blood stream lowers around 30%.

Like Viagra, food with a high concentration of fat also retards the uptake of Levitra for up 1 hour. Additionally, the highest accumulation decreases up to 20%.

the presence of high fat food does not decrease the effect of Cialis on the other hand. One can take this ED pill with no concern regarding food with high fat content.

The consumption of alcohol does not affect Levitra, Cialis or Viagra. However, excessive consumption of alcohol is a factor in decreased sexual performance.

Comparative half-lives of ED pills

PDE5 blockers continue to be active for different spans of time and this is usually expressed half-lives.

Cialis has a half-life of 17.5 hours which means that if a sufficient amount is digested it stays in effect for up to 36 hours.

Viagra and Levitra have a half-life duration of approximately 4 hours providing an active footprint of around 8 hours.

All three PDE5 blockers are eliminated from the subject by route of normal bodily excretion.

To be more specific, PDE5 inhibitors are removed from the blood by means of hepatic metabolism. The metabolite N-desmethyl is the by-product of metabolised Viagra PDE5 inhibitor Sildenafil that additionally displays PDE5 inhibiting properties. This by-product of Sildenafil stays up to 20% as active as the initial oral PDE5 inhibitor Sildenafil.

The metabolite by-product of Levitra has just a 7% strength of the original PDE5 inhibitor Vardenafil.

Cialis oral PDE5 inhibitor Tadalafil provides no useful metabolites subsequent to metabolic action.

Viagra, Cialis and Levitra comparison – activation time comparison

All 3 ED pills in this comparison, Levitra, Cialis and Viagra, are not immediately effective after swallowing. Test results have shown that there remains considerable range among all 3 PDE5 blockers. Also there were noticeable variations of activation rates among test subjects in this ED pill comparison review.

All 3 PDE5 inhibitors are active between 30 minutes to 1 hour after taking. Test results show considerable variance outside these times however.

The standard line adopted by the professionals in regards to the anticipated delay between swallowing Viagra and its wait for effectiveness to ensure a substantial erection when sexually stimulated is 60 minutes.

Apart from that, one test revealed that some experienced the effects of Viagra in 15 minutes. Reports indicated this activation rate of Viagra in 30% of test subjects.

In results from one test, just more than 20% of test subjects reported being able to enjoy sufficient erections capable of sexual intercourse within 10 minutes after swallowing 10mg of PDE5 inhibitor Vardenafil (Levitra). The standard recommendation for Levitra is to start it at least 30%r prior to attempting intercourse.

The standard advice for Tadalafil (Cialis) is to take it at least half an hour prior to attempting sexual intercourse. One study has suggested that some 15% of the patients achieved the capacity to preform penetration within 20 minutes.

Comparison of effectiveness duration

The PDE5 inhibitors that form the basis of Cialis, Levitra and Viagra have different time-scales in their effectiveness. Normal information that ships with Viagra and Levitra state up to five hour time-scale during which the ED pill remains effective.

Cialis on the other hand enjoys a half-life of 17.5 hours. The effectiveness of this ED pill is effective for up to 36 hours plus. Consequently it people refer to it as ‘the weekend pill’. This makes Cialis a top selection ED pill for men who seek more spontaneous sexual activity.

Results from the lab demonstrate that all 3 ED pills compared are beneficial for a wide range of erectile dysfunction sufferers. At this time there still is a gap in direct tests to compare the Ed pills Cialis, Levitra and Viagra.

ED pill comparisons of relative potency

Improvement for ED sufferers coming from a 3 month test of trying the ED pills involving:

  • over 100 subjects trying Levitra,
  • approx. 300 subjects trying Viagra,
  • over 1,000 subjects ingesting Cialis,

resulted in the following numbers:

75% of the subjects who ingested Viagra 50 mg had erections when sexually aroused. Only 16% of subjects had similar results with a placebo.

80% of the subjects who ingested Levitra 20mg experienced erections when sexually stimulated. Only 40% of patients who took a placebo experienced similar results.

All the subjects of the tests where in their mid-50’s. They previously had various degrees of ED ranging between occasional failure to total failure for up to 6 years before the test trials took place.

84% of the subjects who ingested Cialis 20mg experienced erections when sexually stimulated. Only 33% of patients who took a placebo experienced similar results.

These studies included patients in their late50’s who had suffered ED for at least a year. The severity of erectile dysfunction experienced by the patients alternated between moderate 40% to extreme 60%.

Testers excluded subjects who had failed to respond positively to PDE5 inhibitors in the past.

After the tests were completed it was directly asked:

Was your erection of adequate firmness and long lasting enough to engage in full intercourse?

The answer ‘yes’ to this question was 65% for Viagra and Levitra, and 68% for Cialis.

ED pills aims and preferences

The primary focus of ED pills such as Viagra, Levitra and Cialis is to enable satisfactory capability for erections when sexually aroused leading to an enjoyment of a full and satisfying sex life. Doctors must consider the requirements and distinct preferences of the patient when prescribing ED pills.

The response rate and effectiveness of the three easily available ED pills are more or less the same. Doctors must consider the interests of the patient prior to making a prescription.

Comparison of ED pills preference

To compare men’s choice between Cialis and Viagra a lab test used approximately 200 subjects. The doses were a flexible amount of Sildenafil (Viagra) and 20mg of Tadalafil (Cialis).

Subjects taking Viagra started on 50mg with the ability to increase the dose.

Because advice concerning duration for Cialis and Viagra are distinct, testers used placebos mimicking both PDE5 inhibitor’s advice to ensure blindness.

Additionally a random selection for which patients used Cialis and Viagra with a 3 month exchange from one treatment to the other one. At the end of the lab study there remained 180 men who could be regarded as appropriate to choose which ED pill they preferred to continue with.

Preference for Cialis

generic Cialis pillAt the end of the blind lab test the results showed that approximately 75% of the subjects preferred Cialis vs Viagra as their preferred ED pill.

Another lab study employed subjects taking doses of Sildenafil between 25mg to 100mg for a time-scale of 6 weeks, prior to changing to Cialis 20mg.

This ED pill comparison test attempted to mimic normal test practice. The resulting figures demonstrated beyond doubt that close to 90% of the subjects favored Cialis vs Sildenafil.

In another ED pill comparison test conducted in Ireland to discover the preference between Cialis and Viagra, over 300 men participated in the study lasting 3 months for each ED pill.

The first two months trying either Cialis or Viagra was the dosage selection phase. Men chose the most appropriate dose for each ED pill. The subjects were started with 25mg or 50mg of Viagra. They could increase the dosage to 100mg. Subjects also began with 10mg of Cialis and could increase the strength to 20mg if the chose to.

Viagra 33%, Cialis 66%

At the end of 12 weeks of this ED pill comparison study of Cialis vs Viagra, testers offered the subjects a choice on which ED pill they wished to continue with. 33% of the subjects wished to stay with Viagra and 66%decided to remain on Cialis.

3% of the men quit because of negative side effects and less than 1% dropped out the lab study due to a lack of any significant beneficial result.

These two ED pill comparative studies clearly indicate that subjects choose their preferred ED medication founded on the actual effects. Nevertheless the methods employed in these studies of ED treatments the subjects’ choice used techniques that may have introduced bias in decision making.

Questions about comparative study methods were discussed such as failures in blindness, pattern of medication switch, and changing dosage strengths and instructions. The information varied due to the differences in duration and influence of food on the effectiveness of Viagra and Cialis.

Keeping in mind that the men were provided dosage instructions tailored to the ED pill being used (Cialis or Viagra) during that phase, it would be doubtful that any negative reaction or experience of its effectiveness were effected by the methods of the test study

Although this test study admitted possible discrimination, more in depth studies are being undertaken to clearly identify erectile dysfunction sufferers’ preference of the 3 main PDE5 inhibitors – Levitra (Vardenafil), Viagra (Sildenafil) and Cialis (Tadalafil).

ED pills price comparisonED pills comparison wrap up

Due to the interest and wide-spread use of ED pills, the complexity and price to acquire these impotence treatments marketed as Cialis, Levitra and Viagra have fallen considerably.

The 3 readily available Ed pills are a cost-effective approach to overcome over 90% of impotence cases. Being effective for a far longer period, Cialis is the most cost-effective ED pill especially if the user wants to continue to use Ed treatments over many years.

Considering ED treatments available, ED pills remain the most effective and affordable approach to curing ED. All 3 main ED pills, Cialis, Levitra and Viagra, enjoy the same properties. All are effective and have few negative side effects by the vast majority of users.

Doctors must keeps in mind the differences among these PDE5 inhibitors when prescribing ED pills. It is essential that each ED sufferer gets the appropriate treatment for his needs.

The Levitra vs Viagra vs Cialis comparison contention is seemingly endless. However, by preference, Cialis comes out on top every time. Also, ED pill comparisons show that Levitra and Viagra are more successful in curing ED overall.

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ED pills online price comparison

Before you go to these cheap ED pills online price comparisons, you can find tips on more ways to save money when buying erectile dysfunction medications online below.

Which ED pill is best?

Viagra was the fist ED pill to hit the market and has therefore enjoyed the largest market share for some time. However, with the introduction of Cialis, a tadalafil-based oral PDE5 inhibitor, the choice is staring to swing.

There are two main reasons for this change.

Cialis remains active in the body enabling men to achieve significant erections for up to 36 hours after ingestion. This allows men taking Cialis to engage in more spontaneous sex. It removes the fear of the effects wearing off just when they need them.

Viagra and Levitra on the other hand are only effective for around 6 hours.

Another advantage of Cialis is that it doesn’t block PDE6. PDE6 is an enzyme that affects vision. Viagra and Levitra both, to some degrees, inhibit PDE6. This can lead to side effects of visual distortion.

Taken together, the less side effects of Cialis and its long duration make it he preferable choice of ED medication for men in the know.

Having said that, note that some ED pills work better for some men than others. If I just starting off using ED pills I would try different types to see what works best for me. If I were to start with one type ED medications I would try Cialis or some other Tadalafil based erectile dysfunction pill.

 

Money Saving Tips for Buying ED Pills Online

The quantity you buy and the dose you buy can make a real difference to the price per  ED pill. Order in bulk and consider pill-splitting. You can often cut the price of even the cheapest generic ED pill even more. Think about price per dose, rather than price per pill.

The other thing to watch out for when buying ED pills online is that you don’t get caught out by hidden fees. Watch out for prescriptions or consultations fees, or excessive shipping costs

Most of the pharmacies listed here offer free shipping, and don’t charge fees for online consultations (e.g., for going through a questionnaire process in order to get your online prescription). That’s another reason these ED pills online price comparisons are useful.

And the ED pills online price comparisons also indicate whether a prescription is required before you place your order. In most cases it isn’t, which means you can buy generic ED pills online without a prescription. Instead you’ll just go through a simple consultation process when you place your order so it can be approved.

Alright, well I hope these ED pills online price comparison tables help you out. It took a fair bit of time doing the research, but hey – I benefited 😉 I hope you do too.

 

Viagra vs Cialis vs Levitra (ED pills comparison part 2)

Viagra vs Cialis vs Levitra part 2 of ED pills comparison

Viagra vs Cialis vs Levitra half-lives

Viagra vs Cialis vs LevitraPhosphodiesterase type 5 inhibitors remain effective for different lengths of time and this is expressed in ‘half-lives. Cialis has a half-life of 17.5 hours. If a sufficient dosage is taken it can remain effective for up to 36 hours. Levitra and Sildenafil have a half-life of approximately 4 hours. It has an effective footprint of up to 8 hours if a large enough dosage for the subject is digested.

PDE5 inhibitors are removed from the blood stream via hepatic metabolism. The metabolite N-desmethyl is the by-product of metabolised Sildenafil. This also exhibits PDE5 blocking characteristics. Up to 20% effective of Sildenafil itself. The metabolite remaining from Levitra in comparison only has a 7% effectiveness of the initial PDE5 inhibitor. Cialis exhibits no active metabolites subsequent to breakdown.

The body eliminates all oral phosphodiesterase type 5 inhibitors via normal bodily excretion.

ED pills price comparison

Viagra vs Cialis vs Levitra – testing PDE5 inhibitor time delay in effectiveness

Neither Sildenafil, Levitra nor Cialis are effective immediately after consumption. Test results have shown that there is considerable variation between these 3 PDE5 inhibitors. There are also considerable differences among the test subjects in this regard.

On average all 3 PDE5 inhibitors become active between half an hour to 1 hour after ingestion. However, researchers noted considerable divergence outside these time parameters.

Medical and pharmaceutical industry recommends 60 minutes between taking Sildenafil orally and its time of most effectiveness.

However, one study showed that 35% experienced the effectiveness of Sildenafil within 15 minutes.

In another study, 20% of test subjects had erections within 10 minutes after taking 10mg of  Vardenafil. The standard recommendation for Vardenafil is to take it 25 to 60 minutes prior to intercourse.

The standard recommendation for Cialis is to take it at least 30 minutes before intercourse. One study has shown that 16% were able to preform intercourse in under 20 minutes.

 Viagra vs Cialis vs Levitra – duration of effectiveness

The three PDE5 inhibitors used in Viagra, Levitra and Cialis have different lengths of duration in their effect. Standard information supplied with Levitra and Sildenafil suggest a 4 to 5 hour duration when the treatment remains effective.

Tadalafil on the other hand has a half-life of 17.5 hours. Researchers consider the effects of Cialis and other Tadalafil-based ED treatments effective for up to 36 hours. Hence the nickname ‘the weekend pill’. This length of effective duration makes Tadalafil a top choice.

Tests have shown that all 3 PDE5 inhibitors are effective for a broad spectrum of subjects. Currently there still is a lack of direct comparative tests of the ED medications Levitra, Cialis and Viagra. Researchers need more head to head comparative tests of these PDE5 inhibitors. Then researchers can determine a definitive pronouncement of their effectiveness.

Viagra vs Cialis vs Levitra – efficacy tests

Beneficial change arising from a 3 month trial of taking theses ED treatments involving between 150 subjects on Levitra, 320 subjects on Viagra and over 1,000 subjects taking Cialis. It resulted in the following figures:

75% of the subjects who took 50 mg of Viagra reported an improvement of erections over the course of the test. Only 16% of those who took a placebo reported and improvement.

For those who took 20mg of Levitra over a 3 month period, 82% reported an significant improvement. In the same test 39% of subjects who took a placebo reported a similar improvement.

All the subjects where in their late 50’s. They had previously experienced levels of erectile dysfunction ranging from mild to severe for up to 6 years previously.

In another 12 week study of the efficacy of Cialis, 84 percent of test subjects reported an significant improvement. Of those taking a placebo, 33% reported an improvement.

These studies included men in their late 50’s who had suffered erectile dysfunction for more than 1 year. The degree of erectile dysfunction suffered by the patients ranged from moderate 45% to severs 65%.

Test subjects who had previously failed to respond to PDE5 inhibitors were excluded from these trials.

In the tests cited above it was asked: Was your erection of sufficient strength and duration to have full intercourse? A positive response to this question was 65% for Viagra and Levitra, and 68% positive for Cialis.

Viagra vs Cialis vs Levitra in patients with health conditions and other medications

The use of PDE5 inhibitors are effective with those who suffer from diabetes, clinical depression and cardiovascular disease.

Studies were in accord with the European regulatory framework for prescription medications. All three used PDE5 inhibitors, Levitra, Cialis and Viagra. They can be used to treat patients with cardiovascular disease with the proviso that they have currently taking nitrates.

One test result indicated that there was a 71% success rate for patient who tried a PDE5 impotence treatment who were also at risk for cardiovascular disease.

There is a caution in place however against using Viagra while at the same time being on alpha blockers for hypertension. Combining these to prescription increases the risk of suffering hypotension. Experts do not recommend doses of Viagra over 25mg for those currently on a daily dosage of alpha-blocker medication.

Many consider Levitra potentially beneficial for those patient with hypertension and cardiovascular problems. There has yet to be definitive tests results to back this association.

Researchers do not recommend combining alpha blockers with Levitra. Not until the subject has achieved a fixed regime of alpha blocker intake and their condition is stable.

Researchers recommend that the maximum dose of Vardenafil is kept to 5mg. Even this modest dosage of this PDE5 inhibitor one should not take one within 6 hours of alpha blocker ingestion.

Similar to Levitra, Cialis has similar benefits for men with erectile dysfunction and hypertension issues and those with cardiovascular risk factors.

The European Union recommends that alpha blockers and Tadalafil (Cialis) should not be taken in conjunction.

Despite this, one study involving around 20 subjects showed that Cialis had no measurable impact on blood pressure.

Viagra vs Cialis vs Levitra – effects of on men with diabetes

PDE5 inhibitors such as Viagra, Cialis and Levitra are effective in men who suffer from ED and diabetes. After being treated for ED with Viagra well over 50% of the subjects of this group reported improvement in erectile function. Also ability to engage in sexual intercourse for a sustained period. Doses of Viagra ranged between 25mg and 100mg.  This allowed the subjects of this group to choose for themselves what they felt to be appropriate based on results and how well the subjects in question tolerated this PDE5 inhibitor.

In a similar group of tests subjects, those who suffered from both ED and diabetes, comparable benefits where had with Levitra and Cialis with a 20 mg dose. Tests showed a 71% and 65% success rate with these PDE5 inhibitors respectively.

Viagra vs Cialis vs Levitra  – similarity of negative side effects

Adverse side effects of all three of the most popular PDE5 inhibitors and their prescription pill counterparts, Viagra, Cialis and Levitra, are roughly similar.

As an effect of the vasodilatory effects of these treatments some people experience myalgia, nasel congestion, headaches and dyspepsia.

Another negative side effect associated with the us of these PDE5 inhibitors is hypotension, or when the blood pressure become too low resulting in dizzy spells and lack of stamina. This is most likely when subjects take these PDE5 inhibitors in conjunction with nitrates of nicorandil, a potassium channel blocker. As a result, researchers do not recommend combining PDE5 inhibitors with nitrates or nicorandl.

The differences in selectivity between Cialis, Viagra and Levitra, may account for the differences in side effects. Also when it comes to considering side effects in the operation of the optic nerves.

Occasional reports indicate that some subjects experienced non-arteritic anterior ischaemic optic neuropathy, NAION. It resulted in a temporary loss of vision in a single or both eyes. As a result the US Food and Drug Administration requires all labels to advice health care professionals to desist in proscribing PDE5 inhibitors to patients who experience a loss in vision. However, there have yet to be verifiable test results that conclusively tie the use of PDE5 inhibitors with temporary loss of vision.

Viagra vs Cialis vs Levitra – failure of response rate

Not all men who experience chronic erectile dysfunction respond positively to PDE5 inhibitors.

Test studying failure rates of popular ED medications like Cialis, Viagra and Levitra do not consider it a permanent failure to respond until the maximum dose of each PDE5 inhibitor fails for 8 or more consecutive time.

One study involved over 130 subjects. Failure to respond to Viagra was turned into responsiveness after psychological therapy for over 50% of the subjects. Sujects must experience sufficient sexual arousal prior to experiencing the beneficial effects of PDE5 inhibitors.

Additionally, researchers found that some men who remain unresponsive to some PDE5 inhibitors are responsive to other ones – although the reasons remain unclear.

However, some men who fail to respond t PDE5 inhibitors initially discover that a continuous expose to these ED medications can result in a decrease of ED symptoms over a course in time

Another reason some subject fail to respond to popular ED medications such as Viagra or Cialis is due to a dearth of the hormone androgen. Researchers do not recommend ED medications for cases androgen replacement therapy.

Researchers recommend that referral to specialists is the best course of action for those who do not respond adequately to oral phosphodiesterase type 5 inhibitors.

Viagra vs Cialis vs Levitra – Impotence treatment goals and preferences

The main goal of ED treatments like Viagra, Cialis and Levitra is to restore full erectile capacity when sexually stimulated as a consequence to enjoy a full and satisfying sex life.

Medical professionals must note the needs and individual preferences of the patient when prescribing the available ED medications.

Given that the response rate and effectiveness of the three major PDE5 inhibitors are similar, the preferences of the patient must be duly considered prior to continuing prescription.

Preferences for Tadalafil over Sildenafil

To measure patient preference between Tadalafil (Cialis) and Sildenafil (Viagra), researchers used a double-blind crossover test study with 200 subjects. The doses were a flexible dose of Viagra and 20 mg of Tadalafil for the Cialis.

Those taking the Viagra started on 50 mg with the option to increase the dose limited to 35% of the test subjects to repeat patterns found in clinical practice.

Due to the fact that instruction regarding duration for Cialis and Viagra are different, researchers used placebos mimicking both medication instructions to maintain blindness and impartiality.

There was also a random selection as which subjects received Cialis and Viagra with a 12 week crossover from.. At the end of the study 180 subjects could make a choice over which ED medication they preferred.

At the end of the blind test researchers discovered that approximately 70% of the test subjects clearly chose Cialis vs Viagra as their preferred ED medication

Another study where Cialis is preferred

Another study involved patients experimenting with doses of Viagra ranging from 25 mg to 100 mg for a period of 6 weeks Then they switched over to Cialis at a fixed dosage of 20 mg.

This test attempted to mimic normal clinical practice. The results showed definitively that around 90% of the test subjects chose to continue with Cialis vs Viagra.

In another study conducted in Europe tested the preference for Viagra vs Cialis. Over 350 subjects participated. The trial lasted 12 weeks for each PDE5 inhibitor.

The first 8 weeks trying either Viagra or Cialis was the ‘dose optimisation’ phase.  The subjects established the best dosage amounts for each respective PDE5 inhibitor. The subjects started with 25or 50 mg of Sildenafil. They could then up the dosage to 100 mg if they chose to. Subjects also started with 10 mg of Cialis and could up the dosage to 20 mg if they chose to.

Researchers gave the subjects a choice on which ED medication they would choose to continue with after both 12 week phases with Viagra vs Cialis

30% prefer Viagra, 70% prefer Cialis

30% of the subjects chose to continue with Viagra and 70% chose to continue with Cialis.

The choices made did not influence the order or sequence of testing, degree of erectile dysfunction experienced beforehand, the subjects age or dosage desired. 3% of the test subjects discontinued due to adverse effects and .08% discontinued due to lack of any beneficial effect.

These two studies clearly demonstrate that users select their preferred ED treatment based on pharmacological considerations. However the methods used in these studies of ED medication user preference employ methods that could introduce some bias in decision making among the subjects of the study.

Methodological problems include gaps in double blinding, adapt ion effects over time, sequence order of crossover, and multiple dosage strengths and instructions. Instructions vary due to the differences in half-life, duration and effect of food upon the performance of Cialis and Viagra.

Subjects understood dosage instructions appropriate for the PDE5 inhibitor tested (Cialis or Viagra) at that phase. It seems unlikely that any adverse reaction of or experience of its efficacy were effected by the methodology of the test.

Even though this test conducted by Eardley et al. accounted for potential biases more comprehensive studies will determine user preference of the three major PDE5 inhibitors Tadalafil (Cialis), Vardenafil (Levitra)and Sildenafil (Viagra).

ED pills price comparison

ED pills comparison summary

Following from the popularity and uptake Viagra the overall complexity and cost of erectile dysfunction management procedures have fallen considerably.

All three available PDE5 inhibitors are an affordable way to treat the vast majority of ED cases. Being effective for a far longer period, Cialis may seem the more cost-effective ED treatment particularly if the user intends on using it in a long-term capacity over many years.

When it comes to ED treatment, oral PDE5 inhibitors remains the most effective, easy to administer, and affordable choice. All 3 of the main PDE5 inhibitors, Vardenafil, Tadalafil and Sildenafil share similar characteristics.  All 3 are effective and well tolerated by the vast majority of users.

It is important however that the medical establishment keeps in mind the differences among these PDE5 inhibitors when prescribing these ED treatments to particular patients. Only then can it be assured that each patient derives the best match for his needs in order facilitate the restoration of his natural and healthy sex life.

Regarding Viagra vs Cialis vs Levitra, Cialis is the clear winner. However ED pills comparison studies indicate that in many instances Levitra or Viagra may be the better choice.

Generic Cialis price comparison – best price generic Cialis online

Cialis online price comparison

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Generic Cialis consists of the active ingredient Tadalafil, a PDE5 inhibitor similar to to Sildenafil (Viagra) and Vardenafil (Levitra).

Cialis 20mg

Generic Cialis erectile dysfunction pill containing Tadalafil PDE5 inhibitor 20 milligrams. One pill will enable a man to achieve a significant and long lasting erection when sexually aroused. Cialis remains effective for up to 36 hours.
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When you click on the the links in the generic Cialis price comparison below you will see generic Cialis at different strengths.

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Cialis 20mg

Generic Cialis erectile dysfunction pill containing Tadalafil PDE5 inhibitor 20 milligrams. One pill will enable a man to achieve a significant and long lasting erection when sexually aroused. Cialis remains effective for up to 36 hours.
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ED pills comparison – Viagra vs Cialis vs Levitra

ED medication comparison of erectile dysfunction treatments Viagra, Cialis and Levitra.

Tackling impotence with Phosphodiesterase Type 5 (PDE5) Inhibitors

ED pills comparisonThe following ED pills comparison study examines the all aspects of the 3 most prescribed ED treatments. These 3 PDE5 inhibitors are the basis of popular ED pills Viagra, Cialis and Levitra.

Tadalafil is the active ingredient in the ED medication Cialis®, manufactured by Eli Lilly. It is the longest lasting of the 3 main ED medications.

Sildenafil is the active ingredient of the ED medication known as Viagra®, a registered trademark of Pfizer who also manufactures this well-known brand.  In 1998 Viagra achieved FDA approval for this first erectile dysfunction in 1998.

Vardenafil, another PDE5 inhibitor is the active ingredient Levitra®, manufactured and distributed by Bayer Pharmaceuticals, a German company most known for its flagship medication Asprin.
ED pills price comparison

The stigma surrounding the condition of erectile dysfunction is dissipating

The discomfort around the treatment of ED, is still present but currently, has decreased. This improvement, to some extent, was a result of the introduction Viagra in 1998 that altered erectile dysfunction treatment. Since then, the popular knowledge of impotence has increased, as has the requests for treatment of impotence.

Concerning the current choices to treat ED, oral phosphodiesterase type 5 (PDE5) inhibitors such as Sildenafil (Viagra), Tadalafil (Cialis) and Vardenafil (Levitra) are the proven method. This ED pills comparison will deal with these three ED treatments currently widely available.

As outlined above, this review compares a number of currently licensed PDE5 inhibitors such as Sildenafil citrate, Vardenafil HCl and Cialis.

All these pills have common effects and structural make-ups. Viagra and Levitra have related molecular characteristics. Cialis is molecularly different in its pharmacokinetic arrangement. This maks ED pills comparison a relatively straightforward project.

ED pills comparison – differences between Viagra, Levitra and Cialis

Capability to enjoy an erection that leads to sexual penetration works for 36% of subjects treated with Viagra in 14 minutes. 24% of men who took Levitra within 11 minutes. 17% of men given Cialis within 15 minutes.

Viagra and Levitra both suffer from half-lives of 4 hours but the half-life of Cialis is around 17 hours.

An additional difference between the PDE5 inhibitors is that meals, especially fatty food, modifies the effectiveness of Levitra and Viagra, but not Cialis.

The different pharmacokinetic characteristics among the oral PDE5 inhibitors could influence user choice, an important and emerging aspect of ED pills.

The arrival of Cialis and Levitra extended the number of options for ED treatment. These treatments share the same method of action as Viagra.

This expanded choice of ED pills allows doctors to consider how they compare in terms of efficacy, safety and convenience.

This ED pills comparison considers this issue by offering a comparative analysis of 3 PDE5 inhibitors: Vardenafil, Sildenafil and Tadalafil.

Erectile dysfunction overview

Erectile dysfunction is a failure to achieve an erection of sufficient stiffness for intercourse. It is often due to aging. It becomes more common in men aged forty and older.

In the past, doctors assumed that erectile dysfunction was a mental issue or just a part of getting older. They tolerated ED with other manifestations of age. Now they know that erectile dysfunction is chiefly due to vascular neurological complications.

Erectile dysfunction can also be a marker of many lesser known physical ailments. For example, men with vascular disorders, cardiovascular disease and diabetes.  These ailments can cause a high incidence of impotence.

Crucially, impotence may frequently prove to be an important marker for undiagnosed organic diseases including:

  • hypertension,
  • diabetes,
  • ischaemic heart disease,
  • hyperlipidaemia,
  • neurological conditions
  • endocrine disease.

Despite greater awareness, erectile dysfunction still remains insufficiently diagnosed and treated by the medical establishment. The stigma associated with erectile dysfunction has decreased, but the discomfort of men confiding in their sexual problems continue to form a barrier to sufficient diagnosis and treatment of ED.

The awkwardness many patients and medical establishment workers feel awkward in openly discussing  sexual dysfunction. This fact delays the best diagnosis and treatments available. As a consequence, many men suffer varying degrees of ED prior to seeking treatment.

Too many governmental health boards give scant attention to ED. As a result not enough research funds come available to study the condition and its treatments.

Most men who suffer ED are fail to secur sufficient treatment. Many in the medical establishment view this  as a lost opportunity to improve men’s overall health, not just ED.

This ED pills comparison review will help address that imbalance.  It  assists both impotence sufferers and those in the medical establishment a clearer idea of the solutions now available.

The role of PDE5 inhibitor ED treatments

Doctors realize that ED medications improve the overall quality of life of the patient. They restore the sexual stamina of the patient to a former state. In order to facilitate more natural forms of sexual expression there is a preference for long lasting erectile dysfunction treatments.

Lifestyles changes for obese subjects are beneficial. It improves sexual function and decrease rates and severity of erectile dysfunction.

Healthy alternatives to erectile dysfunction medications

One study involving 138 men found that for one-third, simply lifestyle changes improve sexual performance. The 2 most important factors were weight reduction and increased cardioid-vascular activity.

However, the majority the erectile dysfunction levels of a majority of subjects did not significantly improve through lifestyle changes. This underscores the fact that ED treatments can do more to effectively overcome impotence in the wider population.

Intrusive alternatives to oral PDE5 inhibitors (ED pills)

Various treatments for erectile dysfunction, including surgery, pumps, injections and internal splints exist. Understandably most men prefer less intensive ED treatments and tablets are usually the first choice. As a result doctors rarely prescribe the more intrusive treatments for ED. More affordable and effective PDE5 inhibitors are now readily available.

Oral treatments such as Viagra, Levitra or Cialis are easy to take as well as having minimal side effects. They all have a high rate of effectiveness. WHO now stipulates these oral treatments as the preferred treatment of ED in the first instance.

The ED treatments with most success are Viagra, Levitra or Cialis. As a consequence both expectations and successful outcomes of ED treatments have increased.

PDE5 inhibitor Sildenafil marketed as Viagra

The first oral PDE5 inhibitors available was Sildenafil:  Viagra, generic Viagra and other brand names such as Kamagra. After the introduction of Viagra, a range of PDE5 inhibitors has become available. Cialis (Tadalafil) and Levitra (Vardenafil) both having slight different characteristics from the original Viagra.

Doctors prefer PDE5 inhibitors as first treatment for erectile dysfunction. Experts do not recommend these PDE5 inhibitors for men who have previously suffered stroke as well as a host of other medical conditions – such as:

  • kidney disease that requires dialysis;
  • cardiac failure; out-of-control hypertension;
  • seriously low blood pressure;
  • significant liver damage;
  • those who have a history of myocardial infarction and angina.

ED specialists recommend doctors consult the detailed information and prescription recommendations for each individual PDE5 inhibitor available to prescribe.

This is due to the fact that  each oral PDE5 inhibitor (or ED pill) has slightly different pharmacological effects.

ED medications – how they work

Here is how the PDE5 inhibitors of Viagra, Cialis, and other ED pills work:

The penis only becomes erect as a result of sexual stimulation. Sexual stimulation results in the release of nitric oxide. This causes the dilation of the blood vessels to the corpus cavernosum, the body of the penis shaft. This is in turn assisted by the growing presence of cyclic guaosine monophoshate, usually abbreviated to cGMP.

Unfortunately for a lot of men, particularly as they get older, the presence of cGMP breaks down by the increasing presence of PDE5.

Sildenafil, Vardenafil and Tadalafil, active ingredients used in erectile dysfunction treatments such as Viagra, Cialis and Levitra, are PDE5 blockers or inhibitors. By reducing the effect of PDE5 present in aging men, these PDE5 inhibitors allow natural erections to occur.

These PDE5 inhibitors only come into play when the cGMP synthesis is present and active.

Viagra, Levitra and Cialis all require sexual arousal to work

Needless to say, Ed pills that employ these PDE5 inhibitors require sexual arousal to become active and their intervention noticed.

After sexual stimulation subject nitric oxide is emitted from neurological synapses adjacent to the penises corpus cavernosum. As a result there forms an accumulation of cGMP manufactured from Guanosine triphosphate (GTP). This results in the relaxation of the muscle tissue. This leads to an erection to the cavity being filled up with blood. PDE5 inhibitors prevent the breakdown of cGMP.  Consequentially, erections to take place with greater ease.

ED pills that use PDE5 inhibitors as the active ingredient are becoming increasing competitive. These ED treatments utilise structures derived from cGMP. In the case of Viagra and Levitra their actual molecular structures are very similar.

In distinction to Sildenafil and Varenafil, Tadalafil, the active ingredient in Cialis, has a alternate chemical structure. However, it retains the principle characteristics needed for the retardation of PDE5.

The differences in chemical structure can be viewed with the pharmaokinetic characteristics inherent in the PDE5 inhibitor Tadalafil. Also, how it interacts with various PDE isozymes and needs attention in an ED pills comparison.

Chemical characteristics of oral PDE5 inhibitors (ED pills)

PDE isozmes have been identified in 11 separate instances. They have been classified according to their amino acid sequence as well as their sensitivity to inhibition. Lab-based research has indicated that the oral PDE5 inhibitors retard PDE isozymes differently.

By and large all phosphodiesterase type 5 inhibitors used effectively suppress PDE5. Nevertheless, the three PDE5 inhibitors that form the basis of this study, Viagra, Levitra and Cialis, have different characteristics when it comes to inhibiting other PDE isozymes.

Selective inhibition of PDE6 and PDE11

Viagra and Levitra can cause vision distortion but not Cialis

Of the 3 PDE5 inhibitors discussed, some also a show propensity to retard the uptake of PDE6, an enzyme that has a factor in controlling the reception of light to optic nerves.

This inhibition of PDE6 affects the perception of color among subjects. It is often described as a bluish tinge. Studies in the laboratory indicate that Viagra and Levitra can result in retardation of PDE6 and as such introduce a slight distortion of vision.

Cialis does not show a similar propensity for PDE6 inhibition.

Studies have shown that Vardenafil has a threefold predilection to inhibit PDE5 over PDE6. Sildenafil has a sevenfold bias to retard PDE5 over PDE6. Tadalafil on the other hand has a seven-hundred-fold prediction to block PDE5 over PDE6.

Tadalafil has a greater predilection to inhibit PDE11 over both Sildenafil and Vardenafil. The function of PDE11 is unclear however.

The body absorbs oral PDE5inhibitors (ED pills) such as Sildenafil, Tadalafil and Vardenafil quickly into the blood stream after ingestion.

Viagra and Levitra achieve peak concentration and effects before Cialis

After ingestion, Viagra reaches a top concentration slightly less than an hour, Levitra reaches its peak plasma concentration in approximately an hour. Cialis takes up to 2 hours to reach its greatest plasma concentration.

ED pills comparison – The effect of food and alcohol

High fat food present in the subjects stomach prior to ingestion slows down the absorption of Levitra and Viagra. It appears to have little if any effect on the absorption of Cialis.

Effect of Viagra and Levitra reduced by fatty food content

High-fat content delays the absorption of Viagra by 1 extra hour. The peak concentration in the blood stream is decreased overall by 30%.

Similar to Viagra,  high fat content slows down the uptake of Levitra for up to 1 hour. Likewise, the peak plasma concentration is reduced by around 20%.

Cialis unaffected by fatty food intake

On the other hand, the presence of fatty foods do not affect Cialis. One can take Tadalafil with little concern over stomach contents as the effects are constant.

The consumption of alcohol doe not seem to affect all 3 oral PDE5 inhibitors, Cialis, Levitra and Viagra. However, excessive consumption of alcohol remains a factor in erectile dysfunction incidents.

next: ED Pills Comparison part 2 – Viagra vs Cialis vs Levitra

 

 

Get Hard Pills

Get Hard pills compared

The three most popular Get Hard pills, or erectile dysfunction treatments, are Viagra Sidenafil (Viagra), Tadalafil (Cialis) and Vardenafil (Levitra).

All 3 of these popular ‘get hard pills’ are composed of PDE5 inhibitors which assist men in achieving significance and long-lasting erections when sexually aroused.

Tadalafil (Cialis)

The most popular ED pill is is generic Cialis (active ingredient Tadalafil)

generic Cialis pill

  • effective 30 minutes to 60 minutes after swallowed
  • half-life of 17.5 hours (effective for up to 36 hours, peaks 2 hours after taking)
  • not affected by food or alcohol
  • standard dosage 10mg to 20 mg
  • available in 10mg, 20mg, 40mg, 50mg, 60mg ,100mg pills
  • as low as $1.92 per 100mg pill (0.38 per 20mg dose)

Sildenafil (Viagra)

Second most popular ED pill is generic Viagra (active ingredient Sildenafil)

Viagra pill

  • effective 30 minutes to 60 minutes after swallowing
  • effective for 4 to 5 hours (peaks 1 hour after taking)
  • not affected by alcohol
  • taken with high-fat foods may decrease absorption by 30%
  • standard dosage 25mg to 50mg
  • available in 25mg, 50mg, 100mg, 130mg, 150mg, 200mg pills
  • as low as $1.92 per 200mg pill (0.48 per 50mg dose)

Vardenafil (Levitra)

Third most popular ED pill is generic Levitra (active ingredient Vardenafil)

generic levitra pill

  • effective 25 minutes to 60 minutes after swallowing
  • effective for 4 to 5 hours (peaks 1 hour after taking)
  • not affected by alcohol
  • taken with high-fat foods may decrease absorption by 20%
  • standard dosage 10mg to 20mg
  • available in 10mg, 20mg, 40mg, 60mg pills
  • as low as $1.58 per 60mg pill (0.53 per 20mg dose)

ED pills comparison

Similarities and differences of popular ED treatments aka get hard pills

Both Viagra and Levitra (active ingredients Sildenafil and Vardenafil) have similar effects. They start to work within 30 minutes after taking and the effects last for up to 5 hours.

 

Cialis (active ingredient Tadalafil) works just like Viagra and Levitra except the effects last for up to 36 hours giving it the nickname ‘the weekend pill’.

Cialis also has the advantage of being less effected by fat-based food in to stomach – so you can have a greasy meal and take Cialis without its effectiveness being reduced.

The main advantage of Viagra is that it is the cheapest of the three main erectile dysfunction medications.

All 3 get hard pills are available to be purchased online in generic form which saves you a bundle of money.

To get the best deals on get hard pills click the links to the price comparison pages below.

Standard doses

Remember that, for most men, 50 mg of Viagra (Sildenafil) is enough for a session, whereas a smaller dose of 20 mg of Cialis (Tadalafil) or Levitra (Vardenafil) will have the same effect.

For the absolute best deal on get hard pills check out the price comparison for these erectile dysfunction pills. Click on a banner below to view:

All 3 of these get hard pills will enable you to achieve significant and long-lasting erections when sexually stimulated. None of these pills will make you have an erection if you don’t want one or are not stimulated sexually.

You can take any of these get hard pills without worrying that your going to have an automatic erection in a potentially embarrassing situation. They only work when you are turned on.

So in other words, you could take a get hard pill and never know the difference unless you are in a situation where getting an erection would be a desirable outcome.

Comparative advantages

get hard pillsThe advantage of taking Cialis (Tadalafil) is that you can take a 20 mg pill any time you want and be ready to achieve an erection when needed within the next 30+ hours. This makes generic Cialis one of the most popular get hard pills on the market today.

Viagra is the original get hard pill and still remains very popular. It is available in 100 mg or more doses. Given that 50 mg of Sildenafil (the active ingredient in Viagra and a number of get hard pills spin-offs, is more that sufficient for most men achieve great enduring erections, a way to get this get hard pill super cheap is to buy large quantities of generic Viagra in large doses and then simply split the pill into appropriate doses.

Levitra works fast. It has rapid action and high effective results. It is also assists with the prevention of premature ejaculation, or PE, enabling men to last longer.Generic Levitra is now available for very reasonable prices when bought online.

If you suffer fro PE on a regular basis, you might want to consider trying a ED & PE combination pill. These pills both help you to achieve a significant erection when aroused and allow you to keep it when engaged in intercourse.

Whichever get hard pill you decide is best for you, you will “be ready when she is” as the saying goes. That can be all the difference between a unsatisfying relationship and one that is really great.

Don’t keep her waiting. Get some cheap get hard pills today. Put that smile back on her face! 😀

 

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